Corynebacterium glutamicum Mechanosensing: From Osmoregulation to L-Glutamate Secretion for the Avian Microbiota-Gut-Brain Axis

After the discovery of Corynebacterium glutamicum from avian feces-contaminated soil, its enigmatic L-glutamate secretion by corynebacterial MscCG-type mechanosensitive channels has been utilized for industrial monosodium glutamate production. Bacterial are activated directly increased membrane tension upon hypoosmotic downshock; thus; physiological significance considered as adjusting turgor pressure releasing cytoplasmic solutes. In this review, we present information that have evolutionally specialized carriers to secrete into surrounding environment in their habitats rather than osmotic safety valves. The lipid modulation activation MscCG production can be explained “Force-From-Lipids” and “Force-From-Tethers” mechanosensing paradigms differs significantly mechanical shock. review also provides on search evidence C. was originally a gut bacterium host with aim understanding roles mechanosensing. is able microbiota help brain function via microbiota–gut–brain axis.